Diabetic Peripheral Neuropathy in Spontaneously Diabetic Torii-Leprfa (SDT Fatty) Rats

Journal of Veterinary Medical Science

Yasuko MERA¹  Takeshi OHTA¹  Mutsuyoshi MATSUSHITA¹  Eimei SATO³  Yusuke KEMMOCHI²  Daisuke TOMIMOTO¹  Takayuki YAMAGUCHI¹  Hironobu TADAKI¹  Tomohiko SASASE¹ 

[1] Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan;Toxicology Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 23 Naganuki, Hadano, Kanagawa 257–0024, Japan;Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Faculty of Agriculture, Tohoku University, 1–1 Amamiya-machi, Tsutsumi-dori, Aoba-ku, Sendai 981–8555, Japan

关键词: diabetes;    diabetic peripheral neuropathy;    nerve conduction velocity;    SDT fatty rat;   

DOI  :  10.1292/jvms.12-0149

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(31)Cited-By(8)Spontaneously Diabetic Torii (SDT) rat is a hereditary model of diabetes. Although the SDT rat shows severe diabetic complications, the onset of hyperglycemia is late. SDT fatty rat, established by introducing the fa allele of the Zucker fatty rat to SDT rat, develops diabetes much faster than SDT rat. In the present study, diabetic peripheral neuropathy (DPN) was evaluated to show the further usefulness of this animal model. Motor nerve conduction velocity (MNCV) was delayed, and the number of sural nerve fibers was decreased in SDT fatty rat. Treatment of pioglitazone lowered blood glucose level and prevented delay of MNCV in SDT fatty rats. SDT fatty rat is a useful animal model for studies of DPN in type 2 diabetes.

【 授权许可】

Unknown