Low concordance between positive antibodies to thyroperoxidase and thyroid ultrasound autoimmune pattern in pregnant women

Endocrine Journal

Zdenek Telicka³  Marie Antošová³  Eliška Potluková³  Tomáš Fait¹  Jana Bartáková³  Štepán Holinka³  Drahomíra Springer²  Jan Jiskra³  Zdenka Límanová³ 

[1] Department of Obstetrics and Gynecology, 1st Faculty of Medicine, Charles University, General University Hospital, 128 08 Prague, Czech Republic;Department of Clinical Biochemistry and Laboratory Medicine, 1st Faculty of Medicine, Charles University, General University Hospital, 128 08 Prague, Czech Republic;3rd Department of Medicine, 1st Faculty of Medicine, Charles University, General University Hospital, 128 08 Prague, Czech Republic

关键词: Thyroid texture;    Thyroid ultrasound;    Antibodies to thyroperoxidase;    Pregnancy;    Preterm delivery;   

DOI  :  10.1507/endocrj.EJ11-0026

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(28)Cited-By(3)The diagnostic and prognostic role of thyroid ultrasound (TUS) in pregnant women positive for antibodies to thyroperoxidase (TPOAb) is unclear.The aim of our study was to compare the relation of ultrasound thyroid texture to the thyroid laboratory tests in pregnant women and controls.Using a semi-quantitative assessment we compared TUS in two groups of women with positive TPOAb and/or with thyroid dysfunction (TSH out of 0.06-3.67 mIU/L): 186 women in 1st trimester of pregnancy recruited from universal screening and 67 asymptomatic age-comparable non-pregnant non-postpartum women recruited from screening of general population (controls).Women with previous history of thyroid diseases were excluded.Only 64/131 (48.9 %) of TPOAb-positive pregnant women were TUS-positive (TUS with autoimmune pattern) in comparison with 35/49 (71.4 %) TPOAb-positive controls (p 10.0 mIU/L if they were TPOAb-positive/TUS-positive as compared to those TPOAb-positive/TUS-negative (8/64 (12.5 %) vs. 0/67 (0 %), p = 0.009).The prevalence of preterm deliveries among TPOAb-positive women was significantly lower if TPOAb-positivity was not accompanied by TUS-positivity (2/67 (3.0 %) vs. 10/64 (15.6 %) in TPOAb-positive/TUS-positive women, p = 0.028).In conclusion, nearly half of the TPOAb-positive pregnant women did not have an autoimmune pattern in TUS.Normal TUS image in TPOAb-positive pregnant women might be a protective factor for preterm delivery.

【 授权许可】

Unknown