Decrease of Intrathyroidal CD161+Vα24+Vβ11+ NKT Cells in Graves' disease

Endocrine Journal

Akira MIYAUCHI²  Fumio MATSUZUKA²  Yoshinori IWATANI¹  Yukiyo NAKAMURA¹  Mikio WATANABE¹  Yuuki TAKAMURA² 

[1] Department of Biomedical Informatics, Division of Health Science, Osaka University Graduate School of Medicine;Kuma Hospital

关键词: Graves' disease;    NKT cell;    Immunoregulation;    Autoimmunity;    Thyroid;   

DOI  :  10.1507/endocrj.K07E-006

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(22)Cited-By(4)To clarify changes in the intrathyroidal natural killer T (NKT) cell subset, which prevents autoimmunity in patients with Graves' disease (GD), we examined intrathyroidal and peripheral lymphocytes in 11 patients with GD and peripheral lymphocytes in nine healthy volunteers using three-color flow cytometry. The proportion of CD161 + T cell receptor Vα24 + Vβ11 + cells, which represent the NKT cell subset, was lower in the thyroid of patients with GD than in the peripheral blood of the same patients and in the peripheral blood of healthy subjects. These results indicate that the proportion of intrathyroidal NKT cells is decreased in patients with GD and that this decrease may contribute to incomplete regulation of autoreactive T cells in GD.

【 授权许可】

Unknown