Urinary albumin and transferrin as early diagnostic markers of chronic kidney disease

Journal of Veterinary Medical Science

Yui SHIBATA²  Kazuyuki SOGAWA²  Akihiro SANDA²  Fumio NOMURA¹  Saori ABE³  Shunsuke MOCHIZUKI⁴  Mamoru SATOH¹  Toshifumi WATANABE⁴  Hiroto MAEDA³  Kazuko SAKAGUCHI⁵  Waka HORIE³  Jun SUZUKI⁵  Wataru SAGIZAKA⁵ 

[1]Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1�?8�?1 Inohana, Chuo-ku, Chiba, Chiba 260�?8677, Japan

[2]Department of Biochemistry, School of Life and Environmental Science, Azabu University, 1�?17�?71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252�?5201, Japan

[3]Maeda Veterinary Hospital, 1�?4�?8 Yamatemachi, Tomakomai, Hokkaido 053�?0851, Japan

[4]Veterinary Teaching Hospital, Azabu University, 1�?17�?71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252�?5201, Japan

[5]Department of Food Biochemistry, School of Life and Environmental Science, Azabu University, 1�?17�?71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252�?5201, Japan

关键词: albumin;    chronic kidney disease;    feline;    transferrin;    urine;   

DOI  :  10.1292/jvms.14-0427

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(19)Cited-By(2)Feline renal diseases are increasingly noted in veterinary practice. It is important to diagnose and identify the pathological basis of renal dysfunction accurately at an early stage, but there are only a few reports on this area in clinical veterinary medicine. We investigated the efficacy of measurement of urinary albumin (u-Alb) and urinary transferrin (u-Tf) for early diagnosis using 5-µl urine samples collected noninvasively by catheterization from normal (IRIS stage I) cats and cats with stage I chronic kidney disease (CKD). The u-Alb levels in normal and stage I CKD cats were 6.0 ± 4.5 and 11.2 ± 8.4 mg/dl, respectively, and the u-Tf levels were 0.09 ± 0.42 and 0.52 ± 0.79 mg/dl, respectively. Based on ROC curve analysis, the sensitivity and specificity of u-Alb and u-Tf were higher than those of the currently used biomarker, the plasma creatinine level. The sensitivity of u-Alb was higher than that of u-Tf, whereas the specificity of u-Tf was higher than that of u-Alb. The validity of the threshold albumin level (20 mg/dl) was confirmed by measurements using SDS-PAGE. Since leakage of u-Tf in urine precedes leakage of u-Alb, inclusion of u-Tf in biochemistry tests may be appropriate for IRIS staging as a diagnostic marker of early diagnosis of renal disorder in cats.

【 授权许可】

Unknown