Linkage Mapping of the Mouse Nephrosis (nep) Gene to Chromosome 15

Journal of Veterinary Medical Science

Tsutomu KUROSAWA¹  Tadao SERIKAWA²  Masaru TAJIMA¹  Munehiro OKAMOTO¹  Norihide YOKOI² 

[1]The Institute of Experimental Animal Sciences, Osaka University Medical School (A9)

[2]Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University

关键词: ICGN mouse;    linkage mapping;    nephrosis;   

DOI  :  10.1292/jvms.63.1347

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(16)Cited-By(4)ICGN is a partially inbred strain of mice with nephrotic syndrome caused by spontaneous glomerular lesion. It has been reported that the albuminuria in ICGN mouse was controlled by at least a single autosomal recessive gene (nep). In this study, we mapped the nep locus by linkage analysis of backcross progeny between ICGN and MSM mice using DNA pooling method. The linkage analysis revealed that the nep locus was localized on the distal part of chromosome 15.

【 授权许可】

Unknown