Journal of Pharmacological Sciences | |
Cyclooxygenase Inhibitors Attenuate Augmented Glutamate Release in Organum Vasculosum Laminae Terminalis and Fever Induced by Staphylococcal Enterotoxin A | |
Mao-Tsun Lin1  Wu-Tein Huang2  Jhi-Joung Wang1  | |
[1] Department of Medical Research, Chi-Mei Medical Center;Department of Health Care Administration, Di Wan College of Management | |
关键词: glutamate; fever; diclofenac; | |
DOI : 10.1254/jphs.94.192 | |
学科分类:药学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(19)Cited-By(8)Both the hyperthermia and augmented glutamate release in the organum vasculosum laminae terminalis (OVLT) after an intravenous dose (30 ng/kg) of staphylococcal enterotoxin A (SEA) were significantly reduced by pretreatment with intravenous administration of cyclooxygenase inhibitors such as aspirin (1 – 10 mg/kg), sodium salicylate (1 – 10 mg/kg), or diclofenac (10 mg/kg). Intra-OVLT administration of 50 – 200 μg in 1.0 μl of either aspirin or sodium salicylate 60 min before or 120 min after an intra-OVLT dose (50 μg in 1.0 μl) of glutamate also significantly suppressed the glutamate-induced hyperthermia. These findings suggest that inhibition of cyclooxygenase receptor mechanisms suppresses SEA fever by inhibition of glutamate release in the OVLT of rabbit brain.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201911300685852ZK.pdf | 233KB | download |