Cyclooxygenase Inhibitors Attenuate Augmented Glutamate Release in Organum Vasculosum Laminae Terminalis and Fever Induced by Staphylococcal Enterotoxin A

Journal of Pharmacological Sciences

Mao-Tsun Lin¹  Wu-Tein Huang²  Jhi-Joung Wang¹ 

[1] Department of Medical Research, Chi-Mei Medical Center;Department of Health Care Administration, Di Wan College of Management

关键词: glutamate;    fever;    diclofenac;   

DOI  :  10.1254/jphs.94.192

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(19)Cited-By(8)Both the hyperthermia and augmented glutamate release in the organum vasculosum laminae terminalis (OVLT) after an intravenous dose (30 ng/kg) of staphylococcal enterotoxin A (SEA) were significantly reduced by pretreatment with intravenous administration of cyclooxygenase inhibitors such as aspirin (1 – 10 mg/kg), sodium salicylate (1 – 10 mg/kg), or diclofenac (10 mg/kg). Intra-OVLT administration of 50 – 200 μg in 1.0 μl of either aspirin or sodium salicylate 60 min before or 120 min after an intra-OVLT dose (50 μg in 1.0 μl) of glutamate also significantly suppressed the glutamate-induced hyperthermia. These findings suggest that inhibition of cyclooxygenase receptor mechanisms suppresses SEA fever by inhibition of glutamate release in the OVLT of rabbit brain.

【 授权许可】

Unknown