Tissue engineering of the gastrointestinal tract for surgical replacement: a nutrition tool of the future?

Proceedings of the Nutrition Society

Tracy C. Grikscheit¹ 

关键词: Tissue engineering;    Gastrointestinal tract replacement;    Animal models;   

DOI  :  10.1079/PNS2003289

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

Optimal nutrition depends on the multiple complex functions performed by the gastrointestinal tract, which range from basic functions such as storage, conduit and mechanical processing to more finely regulated capabilities such as vectorial transport, immune defence and cell signalling. Surgical strategies to supply lacking gastrointestinal tract tissues have relied on either replacement by proxy (surgical substitution) or the introduction of prostheses. Tissue engineering seeks to replace missing tissues with engineered tissues that more accurately reproduce the native physiological and anatomical milieu. It is now possible to engineer several areas of the gastrointestinal tract with high fidelity, and to employ tissue-engineered bowel in replacement in animal models. These replacement models have reflected excellent anatomical and physiological recapitulation of native bowel by the tissue-engineered constructs in vivo.

【 授权许可】

Unknown