Present aspects of organogenesis. Function and thymic involution

Revista Cubana de Hematología, Inmunología y Hemoterapia

Macías Abraham, Consuelo¹  Marsán Suárez, Vianed¹  del Valle Pérez, Lázaro O¹ 

[1] Instituto de Hematología e Inmunología, La Habana, Cuba

关键词: thymic organogenesis;    T cells;    positive selection;    negative selection;    thymic involution;   

DOI  :  

学科分类：生理学与病理学

来源: SciELO

【 摘 要 】

Thymus is a primary organ located in the antesuperior area of the torax. It is the principal place of differentiation and maduration of T cells. In this review present aspects of the embriology, histology and thymic function are detailed, as well as its role in the generation of different kinds of thymic cells; its differentiation to mature cells and of regulator T cells has a crucial role in tolerance induction. Moreover, thymic involution during of immunosenescence process is shown.

【 授权许可】

CC BY-NC