Radiologic images of the thoracic cavity of Golden Retriever dogs affected by muscular dystrophy

Pesquisa Veterinária Brasileira

Feitosa, Matheus L.T.²  Ambrósio, Carlos E.¹  Miglino, Maria A.¹  Alves, Flávio R.²  Pinto, Ana C.B.C.F.¹  Fadel, Leandro²  Gatti, André²  Unruh, Silvana M.¹  Sterman, Franklin A.¹ 

[1] USP;Universidade de São Paulo, São Paulo, Brasil

关键词: Muscular dystrophy;    Duchenne;    Golden Retriever;    dog;    radiology.;   

DOI  :  10.1590/S0100-736X2009000200002

来源: Colegio Brasileiro de Patologia Animal-CBPA

【 摘 要 】

Duchenne Muscular Dystrophy (DMD) is a genetic disorder with clinical signs of muscular weaknesses and progressive atrophy. Golden Retriever dogs show similar genotypic and phenotypic characteristics to Human Muscular Dystrophy and are considered a proper animal model for DMD studies. Latero-lateral and dorso-ventral thoracic radiographies were obtained from 10 Golden Retriever dogs affected by muscular dystrophy, to investigate possible radiographic alterations. Thorax radiographic examination revealed (a) interstitial and alveolar pattern, (b) initial phases of pneumonia and pulmonary edema, (c) cardiomegaly as a principal alteration in the thoracic cavity, (d) megaesophagus displacing the trachea and heart silhouette, and (e) cranial protrusion of the diaphragm lining into the thorax with development of a hiatus hernia displacing the stomach to the caudal mediastinum. Postmortem examination showed pleural effusion, pulmonary emphysema, degenerative and metaplasic processes in the diaphragm and intercostal muscles. Radiographic examination was considered essential for the diagnosis of cardiac and respiratory disease in Golden Retriever dogs affected by muscular dystrophy, and to identify the primary pulmonary process and to provide the establishment of suitable therapeutic treatment, with a reserved prognosis in advanced stage of the disease. Index

【 授权许可】

CC BY-NC