A Clinical Trial of Recombinant Bovine Interferon α1 for the Control of Bovine Respiratory Disease in Calves

Journal of Veterinary Medical Science

Kazuo AKIYAMA¹  Shunji SUGII¹  Yoshikazu HIROTA¹ 

关键词: cattle;    immunomodulation;    inflammation;    interferon;    respiratory disease (bovine);   

DOI  :  10.1292/jvms.55.449

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(17)Cited-By(4)The effects of recombinant bovine interferon α1 (rBoIFNα1) on the incidence of bovine respiratory disease (BRD) were examined in 60 young male cattle. Each group of clinically healthy 30 male cattle was injected intramuscularly with either rBoIFNα1 (5mg/head) or physiological saline 5 times in 6 months. They were examined daily for the clinical symptoms of respiratory distress. The clinical signs of respiratory distress in rBoIFNα1-treated cattle were significantly less severe than those of the placebo group. The incidence rate, relapse rate and mean sick days of respiratory disease in the rBoIFNα1-treated group were 23%, 14% and 4.43 days, respectively, whereas those in the placebo group were 80%, 46% and 6.42 days, respectively. Furthermore, the mean increase of body weights in rBoIFNα1-treated group and placebo group were 1.365 kg/day and 1.340 kg/day, respectively. These results suggest that rBoIFNα1 has a potentially preventive effect on the incidence of BRD.

【 授权许可】

Unknown