Dose-Response Effects of an Aqueous Formulation of Calcitriol and Evaluation of Renal Function in Nonpregnant Cows

Journal of Veterinary Medical Science

Yuji KAWAKAMI³  Kazuhisa FURUHAMA¹  Norio YAMAGISHI¹  Shigeru SATO¹  Kouya SASAKI¹  Izumi ABE⁴  Danil KIM¹  Bhuminand DEVKOTA³  Shuichi OHASHI⁴  Norimoto OKURA² 

[1] United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan;Biei Veterinary Clinical Center, Kamikawa Chuo Agricultural Mutual Aid Association, Hokkaido 071-0200, Japan;Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate 020-8550, Japan;Nippon Zenyaku Kogyo Co., Ltd., Fukushima 963-0196, Japan

关键词: calcitriol;    calcium;    dairy cows;    dose response;    glomerular filtration rate;   

DOI  :  10.1292/jvms.11-0363

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(16)Cited-By(1)Dose responses of plasma calcitriol, calcium (Ca), bone metabolic markers and glomerular filtration rate (GFR) were evaluated in four nonpregnant Holstein cows treated subcutaneously with an aqueous formulation of calcitriol at four doses in a 4 × 4 Latin-square design. Calcitriol, Ca, and markers of bone metabolism were analyzed in plasma samples. GFR was measured in predose and day 5 samples. Plasma calcitriol and Ca concentrations increased dose-dependently. The calcitriol dose was positively correlated with the area under the concentration-time curve of plasma calcitriol. Bone formation markers tended to increase from day 3 onward for all doses. No significant changes in GFR were noted. Thus, exogenous calcitriol administered between 0.0625 and 0.5 μg/kg body weight elicited dose-dependent increases in both plasma calcitriol and Ca and elevated bone formation markers without affecting renal function in nonpregnant cows.

【 授权许可】

Unknown