Terapêutica medicamentosa na isquemia e reperfusão mesentérica: revisão da literatura

Revista Brasileira de Coloproctologia

Pontes, José Carlos Dorsa Vieira¹  Santos, Carlos Henrique Marques dos³  Gomes, Otoni Moreira² 

[1] UFMS;UFMG;FCVSFA

关键词: Ischemia;    reperfusion;    experimental surgery     INTRODUÇÃO A isquemia é uma condição de interrupção no suprimento de oxigênio e nutrimentos para uma determinada área;    durante um período;    devido a uma deficiência de fornecimento de sangue;    o que pode acarretar a morte tecidual1;   

DOI  :  10.1590/S0101-98802006000100003

学科分类：心脏病和心血管学

来源: Sociedade Brasileira de Coloproctologia

【 摘 要 】

A short time ago, it was believed that all of the organic alterations in the mesenteric ischemia were due to the total or partial obstruction of the intestinal arterial flow. As for the physiopathology of the ischemia process and mesenteric reperfusion, recent discoveries demonstrated that the free radicals, mainly, act during the reperfusion taking to the lesion much more important tecidual than the lesions that happen in the ischemia phase separately. So a new therapeutic possibility appears besides the surgical treatment when a certain substance could act in the way to inhibit or to minimize the cascade of alterations at the cellular level that culminate to the cellular lesion and death. We accomplished a wide revision of the current medical literature for the databases LILACS and MEDLINE looking to verify the studied drugs for this gol and the results obtained in the researches. We verified that countless substances have been appraised in experimental studies and most of them didn't show satisfactory results for their acceptance in practice clinic. Although some presented promising results, new studies are still needed to discover a substance that can be used in ischemia situations and mesenteric reperfusion in human beings to avoid interventionist treatments with high mortality rate.

【 授权许可】

CC BY-NC