期刊论文详细信息
Diseases of Aquatic Organisms
Cytomorphology and PCNA expression pattern in bivalves Mytilus galloprovincialis and Cerastoderma edule with haemic neoplasia
Beatriz Novoa1  Antonio Figueras1  Francesca Carella1  Gionata De Vico1 
关键词: Mediterranean mussel;    Common cockle;    Haemic neoplasia;    Proliferating nuclear antigen;    Proliferation indices;   
DOI  :  10.3354/dao02612
学科分类:生物科学(综合)
来源: Inter-Research
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【 摘 要 】

ABSTRACT: Haemic neoplasia (HN) is a pathologic condition reported in several bivalve species in different geographic areas. In this study we describe the cytomorphological features and the proliferative behaviour, assessed by the proliferating cell nuclear antigen (PCNA), of HN in common cockle Cerastoderma edule and Mediterranean mussel Mytilus galloprovicialis. In mussels the presence of at least 5 types of atypical haemocytes was detected, including A- and B-type cells, previously described in M. edulis and Mytilus sp., with predominance of A-type cells in early phases of the disease and B-type cells in more advanced stages. PCNA immunostaining was positive for 97 to 100% of the neoplastic cells, with both cytoplasmic (A cells) and nuclear patterns (B cells). Conversely, in C. edule there was no distinctive morphological cell sub-population, and staining atypical haemocytes with PCNA (range 93 to 100%) showed nuclear expression in early phases of disease and cytoplasmic expression in more advanced stages. The above findings suggest distinct histo-pathogenetic pathways for HN in mussels and common cockles.

【 授权许可】

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