Frequencies of PrP Genotypes in Meat Breeds of Japanese Sheep and Trail of Selective Breeding in Experimental Sheep Flock

Journal of Veterinary Medical Science

Tetsuro TOGARI¹  Naotaka ISHIGURO⁴  Aya KUROKAWA²  Jiro OHARA²  Junko MAEDA²  Hidefumi FURUOKA³  Motohiro HORIUCHI² 

[1] Poultry and Sheep Research Unit, Hokkaido Animal Research Center;Laboratory of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University;Department of Pathological Science, Obihiro University of Agriculture and Veterinary Medicine;Laboratory of Food and Environmental Hygiene, Faculty of Applied Biological Science, Gifu University

关键词: prion;    scrapie;    transmissible spongiform encephalopathy;   

DOI  :  10.1292/jvms.69.1325

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(20)Cited-By(1)The selection of sheep with scrapie-resistant PrP genotypes is one of the control measures for transmissible spongiform encephalopathies in ruminants. In this study, we investigated the frequencies of PrP genotypes in meat breeds in Japan. The nationwide surveillance revealed that nearly half of the Suffolk sheep, a major meat breed in Japan, carried scrapie-susceptible AQ/AQ and AQ/VQ genotypes. In addition, the VQ haplotype, which confers high susceptibility to scrapie within sheep, was also found in Poll Dorset sheep. A trial of selective breeding using sires with scrapie-resistant PrP genotypes AQ/AR and AR/AR could raise the ratio of scrapie-resistant sheep from less than 50% to 80% within 3 years. However, the use of sires with the AR/AR genotype and the selection of ewes would be required to achieve a higher ratio of scrapie-resistant sheep.

【 授权许可】

Unknown