Monocyte Chemoattractant Protein-1 in Dogs Affected with Neoplasia or Inflammation

Journal of Veterinary Medical Science

Yumi SUZUKI¹  Toshinori SAKO¹  Kana TAJIMA¹  Masahiro MIYABE¹  Daigo AZAKAMI¹  Katsumi ISHIOKA¹  Mariko TAKASAKI¹  Yutaka MOMOTA¹  Sumire OHTAKI¹  Akihiro MORI¹ 

[1] Department of Veterinary Nursing, School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1–7–1 Kyonan-cho, Musashino, Tokyo 180–8602, Japan

关键词: canine;    inflammation;    monocyte chemoattractant protein-1 (MCP-1);    neoplasia;   

DOI  :  10.1292/jvms.12-0169

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(15)Cited-By(1)Monocyte chemoattractant protein-1 (MCP-1) is a member of the C-C family chemokines, which mobilizes monocytes from bone marrow to the site of inflammation. To evaluate the clinical utility of canine MCP-1 as a blood test item, we measured serum MCP-1 concentrations in normal and ill dogs. Reference interval of canine MCP-1 was established as 115.6–176.9 pg/ml. Serum MCP-1 concentrations increased in the dogs affected with neoplastic (518.0 ± 84.8 pg/ml), inflammatory (257.0 ± 42.5 pg/ml) or other diseases (360.3 ± 45.2 pg/ml). The results showed high sensitivity of MCP-1 to detect neoplasia and inflammation. Moreover, MCP-1 increased in some cases in which C-reactive protein didn’t increase. MCP-1 might be helpful as a screening blood test marker for detection of neoplasia and inflammation in dogs.

【 授权许可】

Unknown