Journal of Veterinary Medical Science | |
Monocyte Chemoattractant Protein-1 in Dogs Affected with Neoplasia or Inflammation | |
Yumi SUZUKI1  Toshinori SAKO1  Kana TAJIMA1  Masahiro MIYABE1  Daigo AZAKAMI1  Katsumi ISHIOKA1  Mariko TAKASAKI1  Yutaka MOMOTA1  Sumire OHTAKI1  Akihiro MORI1  | |
[1] Department of Veterinary Nursing, School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1–7–1 Kyonan-cho, Musashino, Tokyo 180–8602, Japan | |
关键词: canine; inflammation; monocyte chemoattractant protein-1 (MCP-1); neoplasia; | |
DOI : 10.1292/jvms.12-0169 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
References(15)Cited-By(1)Monocyte chemoattractant protein-1 (MCP-1) is a member of the C-C family chemokines, which mobilizes monocytes from bone marrow to the site of inflammation. To evaluate the clinical utility of canine MCP-1 as a blood test item, we measured serum MCP-1 concentrations in normal and ill dogs. Reference interval of canine MCP-1 was established as 115.6–176.9 pg/ml. Serum MCP-1 concentrations increased in the dogs affected with neoplastic (518.0 ± 84.8 pg/ml), inflammatory (257.0 ± 42.5 pg/ml) or other diseases (360.3 ± 45.2 pg/ml). The results showed high sensitivity of MCP-1 to detect neoplasia and inflammation. Moreover, MCP-1 increased in some cases in which C-reactive protein didn’t increase. MCP-1 might be helpful as a screening blood test marker for detection of neoplasia and inflammation in dogs.
【 授权许可】
Unknown
【 预 览 】
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RO201911300657994ZK.pdf | 472KB | download |