Births of Freemartins Derived from Embryos Reconstructed with Ear Fibroblasts

Journal of Veterinary Medical Science

Woo-Suk HWANG¹  Jung-Keun LEE²  Ki-Yon KIM¹  Dae-Yong KIM²  Jong-Ki CHO¹  Jong-Im PARK¹  Soo-Jung SHIN¹  Sung-Ki KIM¹  Jeong Mook LIM¹  Byeong-Chun LEE¹ 

[1] Department of Theriogenology, College of Veterinary Medicine, Seoul National University;Department of Pathology, College of Veterinary Medicine, Seoul National University

关键词: artificial insemination;    embryo transfer;    somatic cell nuclear transfer;   

DOI  :  10.1292/jvms.63.577

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(6)Although the combination of artificial insemination (AI) and embryo transfer (ET) is effective for preventing large offspring syndrome in clone cattle production, it may cause freemartinism. In this study, 51 reconstructed embryos were transferred to artificially inseminated recipients. Of those 9 twin pregnancies, three delivered male and female offsprings. The females had tufts of long coarse hair and short blind pouch at the vaginal end. At necropsy, hypoplastic testicles and epididymis, which connected to the uterus through the spermatic cord, were found and seminal vesicles were also noted. All females had mixed sex chromosome configuration (60, XX and 60, XY). These results suggest that the combined ET program can cause freemartinism, which reduces the efficiency of clone cattle production.

【 授权许可】

Unknown