Sirtuin 1 suppresses nuclear factor κB induced transactivation and pro-inflammatory cytokine expression in cat fibroblast cells

Journal of Veterinary Medical Science

Shingo ISHIKAWA¹  Hiroshi TAKEMITSU¹  Ichiro YAMAMOTO¹  Makoto HABARA¹  Nobuko MORI¹  Toshiro ARAI¹ 

[1] Department of Basic Veterinary Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1�?7�?1 Kyonancho, Musashino, Tokyo 180�?8602, Japan

关键词: feline;    fibroblast;    inflammation;    NF-κB;    sirtuin;   

DOI  :  10.1292/jvms.15-0245

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(28)Nuclear factor κB (NF-κB) is a key factor in the development of chronic inflammation and is deeply involved in age-related and metabolic diseases development. These diseases have become a serious problem in cats. Sirtuin 1 (SIRT1) is associated with aging and metabolism through maintaining inflammation via NF-κB. In addition, fibroblasts are considered an important factor in the development of chronic inflammation. Therefore, we aimed to examine the effect of cat SIRT1 (cSIRT1) on NF-κB in cat fibroblast cells. The up-regulation of NF-κB transcriptional activity and pro-inflammatory cytokine mRNA expression by p65 subunit of NF-κB and lipopolysaccharide was suppressed by cSIRT1 in cat fibroblast cells. Our findings show that cSIRT1 is involved in the suppression of inflammation in cat fibroblast cells.

【 授权许可】

Unknown