Altered Surface Antigen Expression on Peripheral Blood Mononuclear Cells in Cats Infected with Feline Immunodeficiency Virus

Journal of Veterinary Medical Science

Atsuhiko HASEGAWA¹  Hajime TSUJIMOTO¹  Toshihiro WATARI¹  Kouichi OHNO¹  Ryo GOITSUKA¹ 

关键词: CD4;    CD8;    FIV;    IL-2Rα;    MHC class II;   

DOI  :  10.1292/jvms.54.517

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(27)Cited-By(9)Expression of CD4, CD8, IL-2 receptor α chain (IL-2Rα), and MHC class II (MHC-II) on peripheral blood mononuclear cells were examined in cats infected with feline immunodeficiency virus (FIV). CD4/CD8 T cell ratio in FIV-infected cats was slightly decreased, as compared with that in specific-pathogen-free (SPF) cats. However, there was no statistical differences between them. The number of circulating IL-2Rα+ cells in FIV-infected cats was higher than that in healthy cats, whereas induction of IL-2Rα expression by concanavalin A (Con A) stimulation was depressed in FIV-infected cats. By using two-color cytofluorometry, Con A-induced enhancement of IL-2Rα expression was found to be reduced in both CD4+ and CD8+ populations in PBMC from FIV-infected cats. The circulating MHC-II+ cells were also increased in FIV-infected cats. Furthermore, the induction of IL-2Rα expression on PBMC after Con A-stimulation significantly depressed by FIV inoculation in vitro. These results suggest that FIV activates PBMC in vivo via direct and/or indirect mechanisms, leading to the unresponsive state of T cells to further stimuli in vitro.

【 授权许可】

Unknown