Simultaneous measurement of serum chemokines in autoimmune thyroid diseases: possible role of IP-10 in the inflammatory response

Endocrine Journal

Atsushi Suzuki¹  Hiroya Yamada²  Keiko Yamamoto¹  Mitsuyasu Itoh¹  Eisuke Tomatsu¹  Masaki Makino¹  Izumi Hiratsuka¹  Shuji Hashimoto² 

[1] Department of Endocrinology and Metabolism, Fujita Health University School of Medicine, Toyoake 470-1192, Japan;Department of Hygiene, Fujita Health University School of Medicine, Toyoake 470-1192, Japan

关键词: Chemokine;    Graves’ disease;    Hashimoto’s thyroiditis;    IP-10;    Multiplex assay;   

DOI  :  10.1507/endocrj.EJ15-0448

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(39)Cited-By(1)Autoimmune thyroid diseases (AITDs), including Graves’ diseases (GD) and Hashimoto’s thyroiditis (HT), are the most common autoimmune diseases, and are mainly mediated by T cells that produce cytokines and chemokines in abnormal amounts. Few reports have described the circulating chemokines active in AITDs. Recently, we used a new multiplex immunobead assay to simultaneously measure cytokines and chemokines in small volume serum samples from patients with AITDs. We measured 23 selected serum chemokines in patients with GD (n=45) or HT (n=26), and healthy controls (n=9). GD patients were further classified as either untreated, intractable, or in remission, while HT patients were classified as either hypothyroid or euthyroid. Of the 23 serum chemokines assayed, only the serum level of IP-10 (CXCL10/interferon-γ-inducible protein 10) was elevated, depending on disease activity, in GD or HT compared with healthy controls. However, the serum level of IP-10 was also increased in both untreated GD patients and hypothyroid HT patients, suggesting that levels of this cytokine may not be affected by disease specificity. In conclusion, autoimmune inflammation in patients with AITD is closely related to the level of the serum chemokine, IP-10. Therefore, IP-10 might be a good biomarker for tissue inflammation in the thyroid, but not a useful biomarker for predicting disease specific activity, the progression of AITDs, or responsiveness to treatment because of its independence from thyroid function or disease specificity.

【 授权许可】

Unknown