Effect of Storing Temperature on Hepatotoxicity and Nephrotoxicity of Ifosfamide in Female Rat| Science Publications

OnLine Journal of Biological Sciences

Falah M. Aziz¹ 

关键词: Ifosfamide;    hepatotoxicity;    nephrotoxicity;   

DOI  :  10.3844/ojbsci.2012.21.26

学科分类：生物科学（综合）

来源: Science Publications

【 摘 要 】

Problem statement: Ifosfamide (IFO) is a cytotoxic alkylating drug used for the treatment of a variety of cancers, although it has been found to induce certain hematological, hepatotoxic and nephrotoxic side effects. This drug is widely used in developing country, especially Iraq, but without caring too much to the storing temperature due to low drug maintaining facilities. The present work was achieved to investigate the effect of different temperature degrees on the toxicity of IFO on liver and kidney of female rats. Approach: Ifosfamide (60 mg Kg^-1 b.wt) stored at different temperature degrees (4, 10 and 25

【 授权许可】

Unknown