Effect of Carnosine on Prooxidant–Antioxidant Balance in Several Tissues of Rats Exposed to Chronic Cold Plus Immobilization Stress

Journal of Pharmacological Sciences

Müjdat Uysal¹  Semra Dogru-Abbasoglu¹  Pervin Vural¹  Seval Develi-Is¹  Betül Evran¹  Esra Betül Kalaz¹ 

[1] Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Turkey

关键词: cold plus immobilization stress;    L-carnosine;    prooxidant–antioxidant balance;    liver;    brain;   

DOI  :  10.1254/jphs.12107FP

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(47)Cited-By(8)In this study, we investigated the effect of L-carnosine (CAR) on prooxidant–antioxidant balance in several tissues of rats exposed to chronic stress. Both cold and immobilization stresses were applied to rats at the same time. In the stress group, rats were placed in restraint cages and kept in a cold room (+4°C) for 1 h for 21 days (5 days a week). Rats were injected with CAR (250 mg/kg, i.p.) at 30 min before stress application. Malondialdehyde, diene conjugate, protein carbonyl and nitrotyrosine levels, nonenzymatic (glutathione, vitamin E, and vitamin C), and enzymatic (catalase, superoxide dismutase and glutathione peroxidase) antioxidants were determined in the liver, heart, and brain tissues. Chronic cold plus immobilization stress was observed to affect especially the prooxidant–antioxidant status in the brain tissue of rats. This is the first report showing the beneficial effects of CAR on oxidative stress in the brain in rats exposed to stress.

【 授权许可】

Unknown