Deposition Process of Eosinophilic Substance in Mouse Nasal Septum

Journal of Veterinary Medical Science

Minoru TSUCHITANI²  Takane MATSUI¹  Takuya DOI²  Yuri KOTANI²  Yumi WAKO²  Takeshi KANNO²  Hiroko KOKOSHIMA² 

[1] Department of Pathobiological Science, Obihiro University of Agriculture and Veterinary Medicine;Mitsubishi Chemical Safety Institute Ltd.

关键词: amorphous material;    basement membrane;    eosinophilic substance;    mouse;    nasal cavity;   

DOI  :  10.1292/jvms.71.931

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(8)Cited-By(2)An eosinophilic substance is usually observed in the mouse nasal septum, and its volume increases with age. In contrast to descriptions in textbooks defining the eosinophilic substance as amyloid, our previous report revealed that the observed eosinophilic substance is not amyloid, but consisted of collagen and an amorphous material. Furthermore, it was suggested that the amorphous material was produced by the clear hematoxylin and eosin (HE)-stained nasal gland epithelial cells. In this study, we investigated the deposition process of the amorphous material produced by nasal gland epithelial cells in the interstitium morphologically. In most cases, the amorphous materials in the clear HE-stained nasal gland epithelial cells accumulated at the basal portion. Collagen fibers surrounding the nasal glands partially disappeared, whereas the amorphous material in contact with the rough endoplasmic reticulum of the nasal gland epithelial cells continued to the amorphous material in the interstitium. These findings suggested that the amorphous material produced by the clear HE-stained nasal gland epithelial cells migrated to the interstitium through the partial opening of the basement membrane.

【 授权许可】

Unknown