Pre-pregnancy obesity and maternal nutritional biomarker status during pregnancy: a factor analysis

Public Health Nutrition

Chung-Chou H Chang¹  Laura E Tomedi¹  PK Newby¹  Katherine L Wisner¹  James F Luther¹  Rhobert W Evans¹  Lisa M Bodnar¹ 

关键词: Nutrition;    Pregnancy;    Obesity;    Factor analysis;   

DOI  :  10.1017/S1368980013000736

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

ObjectivePre-pregnancy obesity has been associated with adverse birth outcomes. Poor essential fatty acid (EFA) and micronutrient status during pregnancy may contribute to these associations. We assessed the associations between pre-pregnancy BMI and nutritional patterns of maternal micronutrient and EFA status during mid-pregnancy.DesignA cross-sectional analysis from a prospective cohort study. Women provided non-fasting blood samples at ≤20 weeks’ gestation that were assayed for red cell EFA; plasma folate, homocysteine and ascorbic acid; and serum retinol, 25-hydroxyvitamin D, α-tocopherol, soluble transferrin receptors and carotenoids. These nutritional biomarkers were employed in a factor analysis and three patterns were derived: EFA, Micronutrients and Carotenoids.SettingThe Antidepressant Use During Pregnancy Study, Pittsburgh, PA, USA.SubjectsPregnant women (n 129).ResultsAfter adjustment for parity, race/ethnicity and age, obese pregnant women were 3·0 (95 % CI 1·1, 7·7) times more likely to be in the lowest tertile of the EFA pattern and 4·5 (95 % CI 1·7, 12·3) times more likely to be in the lowest tertile of the Carotenoid pattern compared with their lean counterparts. We found no association between pre-pregnancy obesity and the Micronutrient pattern after confounder adjustment.ConclusionsOur results suggest that obese pregnant women have diminished EFA and carotenoid concentrations.

【 授权许可】

Unknown