Docosahexaenoic acid, protectin synthesis: relevance against atherothrombogenesis

Proceedings of the Nutrition Society

Michel Guichardant¹  Catherine Calzada¹  Fathi Driss¹  Miao Liu¹  Michel Lagarde¹  Ping Chen¹  Evelyne Véricel¹ 

关键词: Blood platelets;    Leucocytes;    Cyclooxygenases;    Lipoxygenases;   

DOI  :  10.1017/S0029665113003704

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

DHA is an abundant nutrient from marine lipids: its specific biological effects have been investigated in human volunteers, taking into consideration the dose effects. We report herein that, at dosages below 1 g/d, DHA proved to be effective in lowering blood platelet function and exhibited an ‘antioxidant’ effect. However, this was no longer the case following 1·6 g/d, showing then a U-shape response. The antioxidant effect has been observed in platelets as well as LDL, of which the redox status is assumed to be crucial in their relationship with atherosclerosis. Second, the oxygenated products of DHA, especially protectins produced by lipoxygenases, have been considered for their potential to affect blood platelets and leucocytes. It is concluded that DHA is an interesting nutrient to reduce atherothrombogenesis, possibly through complementary mechanisms involving lipoxygenase products of DHA.

【 授权许可】

Unknown