Changes in Peripheral Lymphocyte Subsets in the Type 1 Diabetic Dogs Treated with Insulin Injections

Journal of Veterinary Medical Science

Hisashi HIROSE²  Hisashi MIZUTANI²  Sumire SHIMIZU²  Toshinori SAKO¹  Tomohiro YAMAGUCHI³  Yosuke UEMATSU³  Itaru YOSHIMURA⁴  Fumi SAGARA²  Akihiro MORI²  Toshiro ARAI² 

[1] Department of Veterinary Nursing, School of Veterinary Medicine, Nippon Veterinary and Life Science University;Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University;Canine Laboratory Ltd.;Department of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Life Science University

关键词: canine;    diabetes;    lymphocytes;   

DOI  :  10.1292/jvms.70.185

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(19)Cited-By(4)Plasma metabolites and peripheral lymphocyte subsets were measured in ten diabetic and ten control dogs to investigate their significances as indicators to evaluate immune states in the diabetic dogs. Diabetic dogs were treated with insulin injections, however their plasma glucose and fructosamine concentrations were significantly higher than those of the controls. There were no significant differences in counts of total white blood cells (WBC) and lymphocyte CD8+ cells (cytotoxic T cells) between the control and the diabetic dogs. In the diabetic dogs, the counts of CD3+ (T cells), CD4+ (Helper T cells) and CD21+ (B cells) cells and the peripheral lymphocytes CD4/CD8 ratio were significantly lower than those in the control dogs. We confirmed abnormality of lymphocyte subsets in insulin treated diabetic dogs and it may relate to depression of immunocompetence and high susceptibility to common infectious diseases.

【 授权许可】

Unknown