CT-Guided Acetic Acid Injection Therapy for Aldosterone-Producing Adrenocortical Adenoma: A Preliminary Report of Three Cases

Endocrine Journal

TADAICHI KITAMURA¹  YUKIO HOMMA¹  YUTAKA ENOMOTO¹  TAKEO KORENAGA²  SHIGERU MINOWADA¹  TOSHIYUKI KAMIJO¹ 

[1] Department of Urology, Faculty of Medicine, The University of Tokyo;Department of Radiology, Tokyo Teishin Hospital

关键词: Percutaneous injection;    Acetic acid;    Aldosteronoma;   

DOI  :  10.1507/endocrj.47.185

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(14)Cited-By(4)We reported the preliminary outcomes of CT-guided percutaneous injection therapy for aldosteroneproducing adrenocortical adenoma (APA). Five sessions of injection therapy, 4 percutaneous acetic acid injections (PAI) and 1 percutaneous ethanol injection (PEI) were performed in 3 patients with APA. A small amount of acetic acid or ethanol solution was injected via a needle placed precisely inside the tumor. The procedure was frequently monitored by repetitive CT scanning. The follow-up period ranged from 5 to 27 months. After the treatment, hypertension was normalized or controlled by a low dose of conventional anti-hypertensive drug. In 2 of 3 cases the plasma aldosterone levels were normalized. Although temporary symptoms of alcoholic intoxication were observed in the single session of PEI, the 4 sessions of PAI were associated with no adverse symptoms or complications. Although this study covers only short-term results in 3 patients, CT-guided PAI appears to be a safe and effective treatment and may be a promising alternative as a simple and far less invasive therapy for APA.

【 授权许可】

Unknown