Nitric Oxide Modulation of the Spontaneous Firing of Rat Medial Vestibular Nuclear Neurons

Journal of Pharmacological Sciences

Ki-Hyun Cho⁵  Myeong-Kyu Kim⁵  Byeong-Chae Kim⁵  Han-Seong Jeong²  Sung Wook Park⁴  Myung Joo Jang²  Hoo Won Kim³  Tae Sun Kim¹  Jong-Seong Park² 

[1] Department of Neurosurgery, Chonnam National University Medical School;Department of Physiology, Chonnam National University Medical School;Department of Neurology, Chosun University College of Medicine;Department of Pharmacology, University of Minnesota Medical School;Department of Neurology, Chonnam National University Medical School

关键词: nitric oxide;    medial vestibular nucleus;    action potential;   

DOI  :  10.1254/jphs.SCJ04006X

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(4)Modulation of the spontaneous activity of rat medial vestibular nuclear neurons by nitric oxide was investigated using the whole-cell patch-clamp technique. The spike frequency was increased by sodium nitroprusside (SNP), a nitric oxide liberating agent, and it was also increased by another nitric oxide liberating agent, sodium-nitroso-N-acetylpenicillamine. L-Arginine, the substrate of nitric oxide synthase, increased the firing of the neurons. The increased SNP-induced firing was inhibited by 1H-[1,2,4]oxadiazolo[4,3-a]quinozalin-1-one (ODQ), a specific inhibitor of guanylate cyclase. These results suggest that nitric oxide increases the neuronal excitability of the neurons by a cGMP-dependent mechanism.

【 授权许可】

Unknown