Immunohistochemical Analysis of Cyclins in Canine Normal Testes and Testicular Tumors

Journal of Veterinary Medical Science

Kazuyuki UCHIDA¹  Ryoji YAMAGUCHI¹  Susumu TATEYAMA¹  Yuichi MURAKAMI¹ 

[1] Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University

关键词: canine;    cyclin;    seminoma;   

DOI  :  10.1292/jvms.63.909

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(17)Cited-By(3)The expression of cyclins A, D1, D2 and E were examined immunohistochemically in 5 canine normal testes and 31 testicular tumors, including 14 seminomas, 11 Sertoli cell tumors and 6 Leydig cell tumors. In canine normal testes, cyclin A expression was detected in spermatogonia and primary spermatocytes. This suggests that A-type cyclins may play some role in canine spermatogenesis. Cyclin A expression was also observed in 13/14 (92.9%) seminomas and 2/11 (18.2%) Sertoli cell tumors, but no positive reaction was observed in Leydig cell tumors. Parallel examinations for cyclins D1, D2 and E gave negative results in canine normal testes and testicular tumors. High levels of cyclin A expression in canine seminomas indicate that the neoplastic germ cells may be arrested at the spermatogonia and primary spermatocyte stages of differentiation.

【 授权许可】

Unknown