Comparison of the activity of 2 domestic- production factors for granulocyte colonies: Hebervital and Leukocim

Revista Cubana de Hematología, Inmunología y Hemoterapia

Lam Díaz, Rosa María¹  Macías Abraham, Consuelo¹  Matamoros, María de los Angeles¹  Mulens Arias, Vladimir²  Vergara Castellanos, Janet¹  Guerra Segura, Osmel³  González Iglesias, Ana Iris¹  Hernández Ramírez, Porfírio¹  Marsán Suárez, Vianed¹  del Valle Pérez, Lázaro¹  Infante Cristiá, Ena³  Socarrás Ferrer, Bertha Beatriz¹ 

[1] Instituto de Hematología e Inmunología, La Habana, Cuba;Centro de Inmunología Molecular, La Habana, Cuba;Centro de Ingeniería Genética y Biotecnología, La Habana, Cuba

关键词: Granulocyte colony stimulating-factor;    G-CSF;    CD34+ cells;    mononuclear cells;   

DOI  :  

学科分类：生理学与病理学

来源: SciELO

【 摘 要 】

In 35 patients who should have received regenerative cell therapy, it was evaluated the effect of 2 domestic production granulocyte colony stimulating factors: Leukocim and Hebervital for the mobilization of hematopoietic stem cells into peripheral blood. Patients were randomly selected into 2 treatment groups and were given a total dose of 40 mg/kg in 4 sub-doses of 10 mg/kg subcutaneously administered every 12 hours. Count was performed for mononuclear cells and CD34+ cells in peripheral blood by flow cytometry before and after stimulation. There were no statistically significant differences in the counts of CD34+ cells obtained after stimulation with Hebervital and Leukocim.

【 授权许可】

CC BY-NC