Effects of Reticuloendotheliosis Virus and Marek's Disease Virus Infection and Co-infection on IFN-Gamma Production in SPF Chickens

Journal of Veterinary Medical Science

Pu ZHAO²  Zhao-ju TIAN¹  Zhi-zhong CUI¹  Hong-kun ZHAO¹  Hong-mei LI¹  Yu-shu ZHENG¹  Cui-yan LIU¹ 

[1] College of Veterinary Medicine, Shangdong Agricultural University;Department of Animal Science, Henan Institute of Science and Technology

关键词: IFN-gamma Marek's disease virus;    reticuloendotheliosis virus;   

DOI  :  10.1292/jvms.69.213

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(15)Cited-By(6)Two experiments were used to examine the potential role of IFN-γ in chickens infected with reticuloendotheliosis virus (REV) and Marek's disease virus (MDV). First, chickens were infected with REV and/or MDV at 5 days of age and examined from 3 to 50 days post-infection (dpi). In REV+MDV co-infection chickens, IFN-γ ELISA demonstrated a 3-fold increase at 7 dpi compared to the controls, while REV alone caused a 5-fold increase, the IFN-γ levels peaked, and then gradually decreased. IFN-γ levels significantly decreased in MDV infection at 3 dpi and 15 dpi. Second, experiments were designed to determine the effects of different viruses and ConA on IFN-γ production. For REV- or MDV- infected chickens, the IFN-γ levels decreased slightly after adding ConA. This is the first report of IFN-γ production in SPF chickens infected with REV and MDV measured by directly quantitative method.

【 授权许可】

Unknown