Clinical and endocrinological characteristics of adrenal incidentaloma in Osaka region, Japan

Endocrine Journal

Tsunehiko Yamamoto⁷  Keisuke Kosugi²  Soji Kasayama⁴  Tohru Funahashi⁵  Kunihiko Hashimoto^1,11  Ikuo Mineo⁶  Shogo Kurebayashi^1,10  Akihisa Imagawa⁵  Haruhiko Kouhara¹  Makoto Ohashi³  Michio Otsuki⁵  Tadashi Nakamura⁹  Mamiko Tsugawa^1,13  Yutaka Umayahara⁸  Yuya Yamada^1,12  Yukiko Tabuchi⁵  Hideki Taki^1,14  Iichiro Shimomura⁵  Taka-aki Matsuoka⁵ 

[1] Department of Internal Medicine of Endocrinology and Metabolism, National Hospital Organization, Osaka Minami Medical Center, Osaka, Japan;Department of Internal Medicine, Osaka Police Hospital, Osaka, Japan;Department of Internal Medicine, Osaka Rosai Hospital, Osaka, Japan;Department of Medicine, Nissay Hospital, Osaka, Japan;Departments of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan;Diabetes Center, Toyonaka Municipal Hospital, Osaka, Japan;Department of Diabetes and Endocrinology, Kansai-Rosai Hospital, Hyogo, Japan;Department of Diabetes and Endocrinology, Osaka General Medical Center, Osaka, Japan;Department of Internal Medicine, Kawasaki Hospital, Hyogo, Japan;Department of Internal Medicine, Nishinomiya Municipal Central Hospital, Hyogo, Japan;Department of Internal Medicine, NTT West Osaka Hospital, Osaka, Japan;Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan;Department of Endocrinology and Metabolism, Ikeda Munisipal Hospital, Osaka, Japan;Diabetes Center, National Hospital Organization Osaka National Hospital, Osaka, Japan

关键词: Adrenal incidentaloma;    Cushing’s syndrome;    Pheochromocytoma;    Primary aldosteronism;    Non-functioning tumors;   

DOI  :  10.1507/endocrj.EJ15-0404

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(24)The aim of this study was to investigate the clinical and endocrinological characteristics of adrenal incidentalomas in Osaka region, Japan.The study was a multicenter retrospective analysis of 150 patients with adrenal incidentalomas who underwent radiographic and endocrine evaluations between 2005 and 2013.Most adrenal incidentalomas were discovered by computed tomography (77.0%) and the rest were identified by abdominal ultrasonography (14.6%), magnetic resonance imaging (4.2%), or positron emission tomography (4.2%).Adrenal incidentalomas were more frequently localized on the left side than on the right.The average diameter of tumors was 21 ± 11 mm.On endocrinological evaluation, 14 patients were diagnosed with primary aldosteronism (9.3%), 10 with subclinical Cushing’s syndrome (6.7%), 7 with pheochromocytoma (4.7%), 7 with Cushing’s syndrome (4.7%), 2 with both subclinical Cushing’s syndrome and primary aldosteronism (1.3%), and 110 with non-functioning tumors (73.3%).Patients with functioning tumors were significantly younger and had larger tumor diameters than those with non-functioning tumors.Except for hypertension, complications were comparable between patients with functioning and non-functioning tumors, including the presence of glucose intolerance, cardiovascular disease, and dyslipidemia.In conclusion, a higher prevalence of primary aldosteronism was observed compared with a previous report.Complications were comparable between patients with functioning and non-functioning tumors, including the frequencies of glucose intolerance, cardiovascular disease, and dyslipidemia.Long-term follow-up is required in patients with non-functioning tumors because the frequency of complications, such as glucose intolerance, cardiovascular disease, and dyslipidemia, was equal to that in patients with functioning tumors.

【 授权许可】

Unknown