High prevalence and incidence of HIV-1 in a counseling and testing center in the city of Itajaí, Brazil

Brazilian Journal of Infectious Diseases

Janini, Luiz Mario Ramos¹  Arif, Muhammad Shoaib¹  Camargo, Michelle¹  Samer, Sadia¹  Diaz, Ricardo Sobhie¹  Sucupira, Maria Cecilia Araripe¹  Knoll, Rosalie Kupka²  Galinskas, Juliana¹  Giron, Leila Bertoni¹  Grinberg, Gorki¹ 

[1] Universidade Federal de São Paulo, Sao Paulo, Brazil;Universidade do Vale do Itajaí, Itajai, Brazil

关键词: Recent HIV infection;    HIV subtype;    Brazil;    Transmitted drug resistance;   

DOI  :  10.1016/j.bjid.2015.08.001

来源: Contexto

【 摘 要 】

Itajaí is a port city in southern Brazil with one of the highest incidence and mortality rates from AIDS in the country. The prevalence and incidence of HIV infection were investigated in 1085 of 3196 new HIV-1 infection cases evaluated in the counseling and testing center of Itajaí from January 2002 to August 2008. Recent infections were assessed using the BED(tm), and polregion sequencing was performed in 76 samples. The prevalence ranged from 3.08% to 6.17% among women and from 10.26% to 17.36% among men. A total of 17% of infections were classified as recent, with annual incidence varying from 1.6% to 4.8 per 100 patient/year among women and from 2.05% to 8.5 per 100 patient/year among men. Pol sequences were obtained from 38 randomly recent infections selected individuals: 71% were infected by subtype C, 24% B, 2% D, and 2% F1. Among 38 subjects with established infection, 76% were subtype C, and 24% B. Transmitted drug resistance was detected in 18.4% of recent infection subjects (7.8% to nucleoside analog reverse-transcriptase inhibitors, 5.2% to non-nucleoside reverse-transcriptase inhibitors, and 5.2% protease inhibitors) and 5.2% of subjects with established infection had nucleoside analog reverse-transcriptase inhibitors resistance. The high prevalence and incidence of HIV infection in this region is unprecedented in studies involving cases evaluated in the counseling and testing centers in Brazil.

【 授权许可】

Unknown