Changes in serum thyroglobulin antibody levels as a dynamic prognostic factor for early-phase recurrence of thyroglobulin antibody-positive papillary thyroid carcinoma after total thyroidectomy

Endocrine Journal

Ayako Nakayama¹  Tomonori Yabuta²  Akihiro Miya²  Minoru Kihara²  Yasuhiro Ito²  Hiroo Masuoka²  Kaoru Kobayashi²  Mitsuhiro Fukushima²  Osamu Yamada¹  Takuya Higashiyama²  Akira Miyauchi² 

[1] Department of Head and Neck Surgery, Kuma Hospital, Kobe 650-0011, Japan;Department of Surgery, Kuma Hospital, Kobe 650-0011, Japan

关键词: TgAb;    Papillary thyroid carcinoma;    Prognosis;   

DOI  :  10.1507/endocrj.EJ14-0275

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(9)Cited-By(4)We demonstrated previously that dynamic prognostic markers such as the thyroglobulin (Tg)-doubling time in thyroglobulin antibody (TgAb)-negative papillary thyroid carcinoma (PTC) and changes in pre- and postoperative TgAb levels in TgAb-positive PTC patients more keenly reflect patients’ prognosis than conventional static prognostic factors.Here we investigated periodic changes in TgAb levels in 513 TgAb-positive PTC patients who underwent total thyroidectomy.The TgAb levels at 1 year after surgery decreased to <50% of the preoperative values in 407 (79%) patients, and the remaining 106 (21%) patients showed no decrease in TgAb.In 426 patients, TgAb was also measured more than 1 year after surgery.Compared with their TgAb levels 1 year after surgery, 59 patients (14%) showed an increase in TgAb levels of >20% during the follow-up.The postoperative Tg levels at 1 year after surgery remained positive in 44 (9%) patients despite their TgAb positivity.To date (median follow-up period 35 months), 12 of the 426 patients (3%) showed PTC recurrence, and 11 of these patients showed either or both a TgAb elevation later than 1 year after surgery and postoperative Tg positivity.Although further studies with longer follow-ups are necessary, we can conclude that changes in postoperative TgAb levels may be usable as a surrogate tumor marker for TgAb-positive PTC patients after total thyroidectomy.

【 授权许可】

Unknown