Pathogenesis and diagnostic criteria for rickets and osteomalacia — Proposal by an expert panel supported by Ministry of Health, Labour and Welfare, Japan, The Japanese Society for Bone and Mineral Research and The Japan Endocrine Society [Opinion]

Endocrine Journal

Toshio Matsumoto⁴  Toshitsugu Sugimoto¹  Seiji Fukumoto⁴  Keiichi Ozono²  Masanori Minagawa⁶  Ryo Okazaki⁷  Toshimi Michigami³  Yasuhiro Takeuchi⁵ 

[1] Internal Medicine 1, Shimane University Faculty of Medicine, Izumo 693-8501, Japan;Department of Pediatrics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan;Department of Bone and Mineral Research, Research Institute, Osaka Medical Center for Maternal and Child Health, Izumi 594-1101, Japan;Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima 770-8503, Japan;Division of Endocrinology, Toranomon Hospital Endocrine Center, Tokyo 105-8470, Japan;Department of Endocrinology, Chiba Children’s Hospital, Chiba 266-0007, Japan;Third Department of Medicine, Teikyo University Chiba Medical Center, Ichihara 299-0111, Japan

关键词: Vitamin D;    Hypophosphatemia;    Hyopcalcemia;    FGF23;   

DOI  :  10.1507/endocrj.EJ15-0289

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(20)Cited-By(1)Rickets and osteomalacia are diseases characterized by impaired mineralization of bone matrix.Recent investigations revealed that the causes for rickets and osteomalacia are quite variable.While these diseases can severely impair the quality of life of the affected patients, rickets and osteomalacia can be completely cured or at least respond to treatment when properly diagnosed and treated according to the specific causes.On the other hand, there are no standard criteria to diagnose rickets or osteomalacia nationally and internationally.Therefore, we summarize the definition and pathogenesis of rickets and osteomalacia, and propose the diagnostic criteria and a flowchart for the differential diagnosis of various causes for these diseases.We hope that these criteria and flowchart are clinically useful for the proper diagnosis and management of patients with these diseases.

【 授权许可】

Unknown