Experimental Infection of Enterotoxemic Escherichia coli Associated with Porcine Edema Disease and its Pathologic Characteristics in the Intestine

Journal of Veterinary Medical Science

Keizo NAKAYAMA⁴  Kazunari USHIDA¹  Takamitsu TSUKAHARA¹  Nobuo NAKANISHI³  Noritaka MATSUBARA² 

[1] Laboratory of Animal Science, Kyoto Prefectural University;Combi Corporation;KYODOKEN Institute;Kyoto Institute of Nutrition and Pathology

关键词: edema disease;    eosinophil infiltration;    experimental infection;   

DOI  :  10.1292/jvms.67.1167

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(26)Cited-By(5)Edema disease (ED) has become frequent in Japan, but no effective method for experimental infection has been developed. We report here the use of a capsule that resistant against gastric digestion to induce the ED in piglets. Four 21-day-old piglets were used. Shiga toxin 2e-producing Escherichia coli (STEC) cell pellet was encapsulated and administered orally. Two pigs received 1.0 × 1010 CFU for two days, and the others received 3.9 × 108 CFU for three days. The high-dose group caused the typical clinical ED signs (palpebral edema or neurologic impairment). Eosinophil infiltration, swollen lymphoid follicles, and edema were observed in the ileum. The kidney had the thrombus in the glomerulus.

【 授权许可】

Unknown