Infection of a Chimeric Simian and Human Immunodeficiency Virus with CCR5-Specific HIV-1 Envelope to Rhesus Macaques

Journal of Veterinary Medical Science

Yoshimi ENOSE¹  Masanori HAYAMI¹  Ariko MIYAKE¹  Eiji IDO¹ 

[1] Institute for Virus Research, Kyoto University

关键词: CCR5;    RANTES;    SHIV;   

DOI  :  10.1292/jvms.65.283

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(28)Cited-By(2)Human immunodeficiency virus (HIV) infects lymphocytes and macrophages via CD4 and chemokine receptors. In this study, the infectivity of a chimeric simian and human immunodeficiency virus (SHIV) having a CCR5-specific HIV-1 envelope gene was examined. A SHIV strain termed SHIV-JRFL could enter cells via CD4 with a chemokine receptor CCR5, not CXCR4, and the viral replication was suppressed by recombinant human RANTES, one of β-chemokines. The intravenous inoculation of SHIV-JRFL into two rhesus macaques resulted in a systemic infection, though it was rather weak. During the early infection, the production of RANTES from Con A-stimulated PBMCs of the infected monkeys increased. These results suggested that β-chemokine has the potential to limit the infectivity of an R5-type SHIV.

【 授权许可】

Unknown