Characterization of progesterone loaded biodegradable blend polymeric nanoparticles

Ciência Rural

Leimann, Fernanda Vitória²  Araújo, Pedro Henrique Hermes de³  Maia, Wallace José²  Biz, Maiara Heloisa³  Sayer, Claudia³  Kaufmann, Karine Cristine²  Cardozo Filho, Lucio¹  Honçalves, Odinei Hess³ 

[1]Universidade Estadual de Maringá, Maringá, Brazil

[2]Universidade Tecnológica Federal do Paraná, Campo Mourão, Brazil

[3]Universidade Federal de Santa Catarina, Florianópolis, Brazil

关键词: progesterone;    drug-polymer interactions;    PHBV;    PLLA;    PCL;   

DOI  :  10.1590/0103-8478cr20141288

学科分类：农业科学（综合）

来源: Universidade Federal de Santa Maria * Centro de Ciencias Rurais

【 摘 要 】

:The encapsulation of progesterone in poly (hydroxybutirate-co-hydroxyvalerate) (PHBV), poly (ε-caprolactone) (PCL), poly (L-lactic acid) (PLLA) nanoparticles and PHBV/PCL and PHBV/PLLA blend nanoparticles was investigated in this research. Nanoparticles were produced by miniemulsion/solvent evaporation technique with lecithin as surfactant and were characterized regarding to z-average diameter (Dz) and polydispersity (PDI), progesterone recovery yield and encapsulation efficiency. Possible interactions between progesterone and the polymer matrices were investigated by Fourier Transform Infrared Spectroscopy (FTIR). High recoveries (up to 102.43±1.80% for the PHBV/PLLA blend) and encapsulation efficiencies (up to 99.53±0.04% for PCL) were achieved and the nanoparticles presented narrow size distribution (0.12±0.03 for PLLA). PCL nanoparticles (217.5±2.12nm) presented significant difference with the Dz from all the other formulations (P<0.05). The most evident interaction between progesterone and the nanoparticles polymeric matrix was found to PHBV/PCL due to the increase in the intensity of the band located in 1631 cm-1.

【 授权许可】

Unknown