Association between insulin-like growth factor binding protein-2 levels and cardiovascular risk factors in Korean children

Endocrine Journal

Il Tae Hwang³  Seung Yang³  Hong Kyu Park⁴  Jung Min Ko⁵  So Chung Chung¹  Eun Young Kim² 

[1] Department of Pediatrics, Konkuk University School of Medicine, Seoul, Korea;Department of Pediatrics, Chosun University School of Medicine, Gwangju, Korea;Department of Pediatrics, Hallym University College of Medicine, Seoul, Korea;Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea;Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea

关键词: IGFBP-2;    Insulin resistance;    Obesity;    Puberty;    Children;   

DOI  :  10.1507/endocrj.EJ11-0358

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(35)Cited-By(1)Emerging evidence has indicated that insulin-like growth factor binding protein-2 (IGFBP-2) may be involved in the development of obesity and insulin resistance like IGFBP-1.The aim of this study was to measure serum IGFBP-2 levels in overweight and obese children and to compare these levels with those of controls.We also analyzed the associations between IGFBP-2 and insulin sensitivity indices and cardiovascular risk factors.134 Korean children including 55 overweight and 59 obese subjects were enrolled.We measured anthropometric values and determined fasting serum levels of IGFBP-2, glucose, insulin, lipid profiles, and insulin sensitivity indices including the homeostatic model assessment of insulin resistance (HOMA-IR) and the Quantitative Insulin Sensitivity Check Index (QUICKI).The subjects were subgrouped based on body mass index (BMI) and pubertal stage, and association analyses between IGFBP-2 levels and measured factors were performed in each group.Serum IGFBP-2 levels in overweight or obese children were significantly lower than those of controls regardless of pubertal development.Serum IGFBP-2 levels were negatively correlated with weight, BMI, waist circumference, fasting insulin levels, and HOMA-IR but were positively correlated with QUICKI.The associations were stronger in pubertal children than those in prepubertal children.However, no association was observed between serum IGFBP-2 levels and auxological or metabolic parameters in children with normal BMIs.These results suggested that IGFBP-2 might be a promising marker for early recognition of insulin resistance, particularly in overweight or obese children, regardless of pubertal stage.

【 授权许可】

Unknown