Aldosterone-Producing Adrenal Cortical Cancer

Endocrine Journal

MASAAKI MORIOKA¹  YOJI FURUKAWA¹  YOZO OHASHI²  HIROYOSHI TANAKA¹  TIE-XIONG JIN²  TATSUYA KOBAYASHI¹ 

[1] Department of Urology, Kawasaki Medical School;Department of Urology, Kochi Medical School

关键词: Adrenocortical cancer;    Hyperaldosteronism;    Hypercortisolism;   

DOI  :  10.1507/endocrj.44.547

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(16)Cited-By(2)A case of hyperaldosteronism caused by adrenal cortical cancer observed in a 32-year-old man was reported. The patient showed marked hypertension and hypokalemia, but neither obesity nor hyperglycemia was observed. Endocrine studies revealed hyperaldosteronism and concurrent excessive secretion of cortisol, but diurnal rhythms of plasma ACTH and cortisol were normal. Imaging studies revealed a large left adrenal mass, and the positive accumulation of radiolabelled material by adrenal scintigraphy was observed both in the tumor and the contralateral adrenal gland. The removed tumor was predominantly composed of dark compact cells with marked nuclear pleomorphism, and mitotic figures and sinusoidal invasion were also observed. The analysis of steroidogenic enzyme activities revealed that the activity of aldosterone-synthesizing enzyme (P-450aldo) which was usually undetectable in normal adrenal tissues and adenomas other than aldosterone-producing adenoma (APA) was detectable as one-third of that of APA. Although activities of other enzymes were reduced, the expression of P-450aldo activity was considered to be the specific character of this cancer.

【 授权许可】

Unknown