Hypokalemic Periodic Paralysis Associated with Thyrotoxicosis, Renal Tubular Acidosis and Nephrogenic Diabetes Insipidus

Endocrine Journal

Hyun Shik SON¹  Jung Min LEE¹  Ho Young SON¹  Bong Yun CHA¹  Sung Dae MOON¹  Eun Joo IM¹  Yu Bae AHN¹  Ji Hyun KIM¹  Kwang Woo LEE¹  Sang Ah CHANG¹ 

[1] Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea

关键词: Hypokalemic periodic paralysis;    Thyrotoxicosis;    Renal tubular acidosis;   

DOI  :  10.1507/endocrj.K09E-261

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(12)Cited-By(1)A 19-year-old girl presented at our emergency room with hypokalemic periodic paralysis. She had a thyrotoxic goiter and had experienced three paralytic attacks during the previous 2 years on occasions when she stopped taking antithyroid drugs. In addition to thyrotoxic periodic paralysis (TPP), she had metabolic acidosis, urinary potassium loss, polyuria and polydipsia. Her reduced ability to acidify urine during spontaneous metabolic acidosis was confirmed by detection of coexisting distal renal tubular acidosis (RTA). The polyuria and polydipsia were caused by nephrogenic diabetes insipidus, which was diagnosed using the water deprivation test and vasopressin administration. Her recurrent and frequent paralytic attacks may have been the combined effects of thyrotoxicosis and RTA. Although the paralytic attack did not recur after improving the thyroid function, mild acidosis and nephrogenic DI have been remained subsequently. Patients with TPP, especially females with atypical metabolic features, should be investigated for possible precipitating factors.

【 授权许可】

Unknown