Effect of Catechins on Mutagenesis of Salmonella Typhimurium TA 102 Elicited by tert-Butyl Hydroperoxide (t-BuOOH)

Journal of Veterinary Medical Science

Satoshi NIKAIDOU¹  Yutaka MAEDA¹  Shoichi FUJITA¹  Akio KAZUSAKA¹  Mayumi ISHIZUKA¹  Yukihiko HARA² 

[1] Laboratory of Toxicology, Department of Environmental Veterinary Sciences, School of Veterinary Medicine, Hokkaido University;Food Research Laboratories, Mitsui Norin Co. Ltd.

关键词: ames test;    catechin;    green tea;   

DOI  :  10.1292/jvms.67.137

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(12)Cited-By(4)Green tea, one of the most popular beverages consumed in Asian countries, has been reported to possess anticarcinogenic and antimutagenic properties. The aim in this study is to test the radical scavenging effect of catechins and caffeine, which were major components of green tea, and if they really prevent oxygen radical-induced mutagenesis. We used TA102 strain of Salmonella typhimurium which is sensitive to hydroxyl radical in the Ames mutation assay. We found that caffeine did not show any effects on mutagenesis in this system, but catechin significantly reduced mutagenesis or genotoxicity caused by hydroxyl radical. This radical-scavenging action of catechins may indeed contribute to the anticarcinogenic activity of green tea as has been proposed.

【 授权许可】

Unknown