NMR of glycogen in exercise

Proceedings of the Nutrition Society

Thomas B. Price¹  Douglas L. Rothman¹  Robert G. Shulman¹ 

关键词: Muscle metabolism;    NMR;    Glycogen;    Exercise;    Insulin;   

DOI  :  10.1017/S0029665199001159

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

Natural-abundance 13CNMR spectroscopy is a non-invasive technique that enables in vivo assessments of muscle and/or liver glycogen concentrations. Over the last several years, 13C NMR has been developed and used to obtain information about human glycogen metabolism with diet and exercise. Since NMR is non-invasive, more data points are available over a specified time course, dramatically improving the time resolution. This improved time resolution has enabled the documentation of subtleties of muscle glycogen re-synthesis following severe glycogen depletion that were not previously observed. Muscle and liver glycogen concentrations have been tracked in several different human populations under conditions that include: (1) muscle glycogen recovery from intense localized exercise with normal insulin and with insulin suppressed; (2) muscle glycogen recovery in an insulin-resistant population; (3) muscle glycogen depletion during prolonged low-intensity exercise; (4) effect of a mixed meal on postprandial muscle and liver glycogen synthesis. The present review focuses on basic 13C NMR and gives results from selected studies.

【 授权许可】

Unknown