Germ-free sea bass Dicentrarchus labrax larval model: a valuable tool in the study of host-microbe interactions

Diseases of Aquatic Organisms

R. Morent¹  M. Schaeck¹  A. Decostere¹  W. Van den Broeck¹  S. Van Nevel¹  N. De Geyter¹  C. Coulombet¹  K. Demeestere¹  F. Haesebrouck¹  L. Duchateau¹  E. De Swaef¹  N. Boon¹ 

关键词: Aquaculture;    Gnotobiotic;    Pathogen;    Larvae;   

DOI  :  10.3354/dao02950

学科分类：生物科学（综合）

来源: Inter-Research

【 摘 要 】

ABSTRACT: A thorough understanding of host-microbe interactions is crucial for more efficient disease management in the marine larviculture industry. As demonstrated in terrestrial animal research, gnotobiotic systems (involving animals cultured in germ-free conditions or inoculated with known microorganisms) are excellent tools to extend our understanding of the mechanisms involved in host-microbe interactions and allow the evaluation of new treatments for diseases. In this study, we introduce a germ-free European sea bass Dicentrarchus labrax larval model, independent of the continuous addition of antimicrobial agents. This model has an experimental set-up that allows addition of live feed to the larvae without compromising the germ-free status. This model will facilitate and render aquaculture research more effective in terms of mitigation fish larval diseases.

【 授权许可】

Unknown