The Cellular Differentiation of M Cells from Crypt Undifferentiated Epithelial Cells into Microvillous Epithelial Cells in Follicle-Associated Epithelia of Chicken Cecal Tonsils

Journal of Veterinary Medical Science

Tomohiro IMAGAWA³  Masato UEHARA³  Takashi TAKEUCHI²  Masashi HOSOKAWA³  Hiroshi KITAGAWA¹  Toshifumi YOKOYAMA¹ 

[1] Department of Life Science, Graduate School of Science and Technology, Kobe University;Institute of Experimental Animals, Shimane Medical University;Department of Veterinary Anatomy, Faculty of Agriculture, Tottori University

关键词: cecal tonsil;    chicken;    differentiation;    gut-associated lymphoid tissue;    M cell;   

DOI  :  10.1292/jvms.65.171

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(21)Cited-By(14)To clarify the cellular origin and the fate of M cells, detailed distributions of the epithelial cells were investigated scanning electron microscopically on the follicle-associated epithelia (FAE) of chicken cecal tonsils. The distribution of M cells was closely related with the situation of the crypt orifices in chicken cecal tonsils. In undeveloped cecal tonsils, the intestinal crypts were localized at the periphery of the FAE. In these tonsils, M cells without microvilli (M0) were predominantly populated in the basal region of the FAE, whereas goblet cells and microvillous epithelial cells (MV) were more distributed in the middle to the apical region of the FAE. A few M cells with short microvilli were dispersed throughout the FAE. Significantly shrunk MV (MVs) clustered together in transitional portions from the lateral face to the roof of the FAE. In well-developed cecal tonsils, the crypts also opened at the lateral surface in addition to the periphery of the FAE. In these tonsils, the M0 accumulated densely in the small areas around the crypt orifices exclusively. No sign of exfoliation of apoptotic epithelial cells was found in the M0-accumulated areas and at their peripheral boundaries. The MVs were often clustered in the central regions among the crypt orifices in addition to the roof of the FAE. These findings suggest that M cells are directly derived from the undifferentiated crypt epithelial cells, not fall into apoptotic cell death and further differentiate into MV in the FAE of chicken cecal tonsils.

【 授权许可】

Unknown