Journal of Veterinary Medical Science | |
Effect of a 7.2% Hypertonic Saline Solution Infusion on Arterial Blood Pressure, Serum Sodium Concentration and Osmotic Pressure in Normovolemic Heifers | |
Kazuyuki SUZUKI1  Shigehiro IWABUCHI1  Tadaharu AJITO1  | |
[1] Central Research Laboratories, Nippon Zenyaku Kogyo Co., Ltd. | |
关键词: heifer; hypernatremia; hypertonic saline solution; plasma volume; serum osmotic pressure; | |
DOI : 10.1292/jvms.60.799 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
References(23)Cited-By(3)The effects of an intravenous (iv) infusion of a small volume (5 ml/kg) or large volume (15 ml/kg) of hypertonic saline solution (HSS; 7.2%, 2,400 mOsmol/kg·H2O) and those of an iv infusion of 5 ml/kg isotonic saline solution (ISS; 300 mOsmol/kg·H2O) on plasma volume, arterial blood pressure, serum sodium concentrations and osmotic pressure were investigated in conscious heifers. Nine heifers (3 heifers/group) were monitored for 120 min after the initiation of fluid replacement. The relative plasma volume (rPV) in the 5 ml/kg HSS and 15 ml/kg HSS progressively increased to 137.7 ± 2.4% at t=5 min and 145.2 ± 5.4% at t=15 min, respectively. The expanding plasma volume in the 5 ml/kg HSS group remained at an up to 10% higher level until 120 min, but not in the 15 ml/kg HSS group. The 5 ml/kg HSS infusion induced transit high-osmotic (305.3 ± 4.0 mOsmol/kg·H2O) and sodium levels (155.7 ± 3.5 mM/l) at t=5 min. However, the 15 ml/kg HSS infusion induced constant high-osmotic level (321.7-336.7 mOsmol/kg·H2O) and hypernatremia (162.8-170.0 mM/l) from t=10 min to the rest of the experiment period. In the ISS and 5 ml/kg HSS groups, no changes in PaO2 were observed. The 15 ml/kg HSS infusion induced a significant decrease in the partial pressure of oxygen at the t=30 min compared to the t=0 min values. On the basis of these findings, a small volume (5 ml/kg) HSS infusion can be rapidly and safely administered to cattle for expanding the plasma volume without inducing hypernatremia. A 5 ml/kg HSS infusion is thus recommended for the initial field resuscitation of cattle.
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