Regulation of Adiponectin Receptor 2 Expression via PPAR-α in NIT-1 Cells

Endocrine Journal

Hwan Ju CHEON⁴  Kyoung Tae LEE³  Yong Jik LEE¹  Jae Min CHO⁴  Tae Woo JUNG⁴  Kun Wook CHUNG⁴  Wan Kyunn WHANG³  Myung Won LEE²  Seon Mee KIM²  Do Hoon KIM⁴  Yeon Taek JEONG⁴ 

[1] Division of Clinical Research, Seoul Medical Center Research Institute;Department of Family Medicine, Brain Korea 21 Project Medical Science, College of Medicine, Korea University;College of Pharmacy, Chung-Ang University;Samsung Biomedical Institute

关键词: Adiponectin receptor 2;    peroxisome proliferator-activated receptor-alpha;    β cells;    Clofibrate;    palmitate;   

DOI  :  10.1507/endocrj.K08E-354

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(29)Cited-By(3)Adiponectin receptors mediate the antidiabetic effects of adiponectin. Although suggested to be mainly expressed in muscle, liver, and adipocyte cells, the expression of adiponectin receptors in β cells is unclear. Given the primary involvement of this cell type in diabetes mellitus, we presently examined the expression level of adiponectin receptor 2 (AdiR2) in β cells. Expression was significantly increased under acute hyperlipidemic conditions but impaired under chronic conditions. The impaired AdiR2 expression may play a role in worsened β cell function. Clofibrate, an agonist of peroxisome proliferator-activated receptor-alpha (PPAR-α) delayed the palmitate-induced impairment of AdiR2 expression and PPAR-α; this delay was abolished by PPAR-α targeted small interfering RNA. The results suggest that AdiR2 expression is regulated by palmit ate via PPAR-α.

【 授权许可】

Unknown