Disc size markedly influences concentration profiles of intravenously administered solutes in the intervertebral disc: a computational study on glucosamine as a model solute

European Spine Journal

A. Shirazi-Adl¹  M. Parnianpour¹  S. Motaghinasab¹  J. P. G. Urban¹ 

[1] Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran

关键词: Intervertebral disc;    Diffusion;    Drug;    Animal models;    Pharmacokinetics;   

DOI  :  10.1007/s00586-013-3142-5

学科分类：骨科学

来源: Springer

【 摘 要 】

Tests on animals of different species with large differences in intervertebral disc size are commonly used to investigate the therapeutic efficacy of intravenously injected solutes in the disc. We hypothesize that disc size markedly affects outcome.

【 授权许可】

Unknown