Basic and Translational Research on Proteinase-Activated Receptors: Proteinase-Activated Receptors in Female Reproductive Tissues and Endometriosis

Journal of Pharmacological Sciences

Yutaka Osuga¹  Yasushi Hirota¹  Yuji Taketani¹ 

[1] Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan

关键词: ovary;    endometrium;    endometriosis;    proteinase-activated receptor (PAR);    reproduction;   

DOI  :  10.1254/jphs.08R13FM

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(13)Cited-By(9)During the menstrual cycle, dynamic morphological changes are observed in the ovarian follicle and the endometrium. These changes are associated with the onset of the inflammatory response in which many proteinases play various roles. Thrombin-induced activation of PAR1 (proteinase-activated receptor 1) stimulates the production of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in human granulosa cells, suggesting a possible role for PAR1 in the ovulatory process. In the endometrium, PAR2 expression increases during the menstrual period. PAR2 activation induces IL-8 production and cell proliferation in human endometrial stromal cells. PAR1 also stimulates proinflammatory cytokine production in human endometrial stromal cells. Thus, the PARs may be important in directing the dynamic changes of the endometrium. PARs also appear to play a role in endometriosis, a common gynecological disease, since activation of PAR1 and PAR2 induces the secretion of inflammatory cytokines and the proliferation of stromal cells in endometriotic lesions. Taken together, PARs appear to play diverse roles in the human reproductive organs.

【 授权许可】

Unknown