Effect of Attenuated Erysipelothrix rhusiopathiae Vaccine in Pigs Infected with Porcine Reproductive Respiratory Syndrome Virus

Journal of Veterinary Medical Science

Takayuki OSUMI¹  Takanori NAMIMATSU¹  Masahumi MORI¹  Katsuyoshi URUNO¹  Tetsuya SAKANO¹  Isao SHIBATA¹  Masaaki ONO¹ 

[1] Zen-noh Institute of Animal Health

关键词: Erysipelothrix rhusiopathiae;    experimental infection;    PRRS;    swine;    vaccine;   

DOI  :  10.1292/jvms.59.977

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(17)Cited-By(1)Twenty 2nd specific pathogen-free pigs were divided into 4 groups: Group A were infected with porcine reproductive and respiratory syndrome (PRRS) virus at 6 weeks of age and treated with available swine erysipelas and swine fever combined vaccine (vaccinated) at 7 weeks of age; Group B were vaccinated at 7 weeks of age and infected with PRRS virus at 8 weeks of age; Group C were vaccinated at 7 weeks of age: Group D were neither vaccinated nor infected with PRRS virus. All pigs were challenged to Erysipelothrix rhusiopathiae C42 strain at 10 weeks of age. No clinical signs appeared after vaccination of group A and B pigs, thus confirming that the safety of the vaccine was not influenced by infection with PRRS virus. None of the pigs in Groups A and C developed erysipelas after challenge exposure to E. rhusiopathiae. In contrast, fever and/or urticaria appeared transiently in all pigs of Group B after challenge exposure. At the time of challenge exposure to E. rhusiopathiae, the PRRS virus titer was high in sera of Group B, but was low in those from Group A. However, vaccination of pigs with attenuated E. rhusiopathiae was effective in dual infection with PRRS virus and E. rhusiopathiae, because the clinical signs were milder and the E. rhusiopathiae strain was less recovered from these pigs compared to pigs of group D.

【 授权许可】

Unknown