Hydrogen Sulfide Causes Relaxation in Mouse Bronchial Smooth Muscle

Journal of Pharmacological Sciences

Satoko Kubo¹  Yuko Kurokawa¹  Atsufumi Kawabata¹  Ichiko Doe¹ 

[1] Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, Japan

关键词: hydrogen sulfide (H2S);    smooth muscle;    bronchodilation;   

DOI  :  10.1254/jphs.SC0070199

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(29)We investigated the effects of NaHS, a hydrogen sulfide (H2S) donor, on the tension of isolated mouse and guinea-pig bronchial rings. NaHS at 0.01 – 10 mM had no effect on the tone of those preparations without precontraction. When the preparation was precontracted with carbachol, NaHS at 0.1 – 3 mM strongly relaxed the mouse rings, but produced only slight relaxation in the guinea-pig rings. The NaHS-induced relaxation in the mouse bronchus was resistant to inhibitors of ATP-sensitive K+ channels, soluble guanylyl cyclase, cyclooxygenase (COX)-1 or COX-2, and antagonists of tachykinin receptors. Thus, NaHS evokes bronchodilation in mice, suggesting a possible role for H2S in the respiratory system.

【 授权许可】

Unknown